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Carcinogenesis In the life time carcinogenicity research completed in B6C3F1 mice, methylphenidate induced an increase in hepatocellular adenomas, As well as in males only, an increase in hepatoblastomas in a daily dose of somewhere around 60 mg/kg/day. This dose is approximately 2 moments the MRHD of sixty mg/day offered to youngsters on mg/m2 bas